Recipes for use in DBPCFC and the importance of blinding
نویسندگان
چکیده
One of the crucial features of double-blind, placebocontrolled food challenge test (DBPCFC) is sufficient blinding of the allergenic food. Blinding is important to avoid any bias during the food challenge. Neither the patient nor the health care professionals involved in the test should be able to identify when the placebo or active test food are being administered. Only if this is guaranteed, the test is actually performed in a double blind fashion. Therefore, without the availability of blinded challenge materials (recipes), true double-blind test conditions cannot be achieved. The validation of challenge materials for adequate blinding can be achieved by sensory testing. Sensory testing should preferably be performed in a professional food laboratory using professional panellists. The second best option is to base the validation on the assessments of volunteers. There is a need for a broad range of validated recipes for the most common allergenic foods in order to cover all age groups, all allergenic foods, to meet the preferences and dislikes of fussy eaters and to take into account cultural eating habits. During the session the availability of validated DBPCFC recipes will be discussed. Participants will be given to chance to participate in a sensory tasting session.
منابع مشابه
Validation of Recipes for Double-Blind Placebo-Controlled Challenges With Milk, Egg White, and Hazelnut.
BACKGROUND The double-blind, placebo-controlled food challenge (DBPCFC) is considered the definitive diagnostic test for food allergy. Nevertheless, validated recipes for masking the foods are scarce, have not been standardized, and differ between centers. Sensory evaluation techniques such as the triangle test are necessary to validate the recipes used for DBPCFC. METHODS We developed 3 reci...
متن کاملDutch guideline on food allergy.
The diagnosis of food allergy is established in cases where an immediate allergic reaction has occurred in the last year to a clearly identifiable allergenic food combined with sensitisation to this allergenic food. In all other cases, a food challenge test is required to establish or reject the diagnosis of food allergy. Although the double-blind placebo-controlled food challenge (DBPCFC) test...
متن کاملDevelopment and validation of a standardized double-blind, placebo-controlled food challenge matrix for raw hazelnuts
Background Double-blind, placebo-controlled food challenge (DBPCFC) is considered the gold standard for food allergy diagnosis. However, this test is rarely performed routinely in clinical practice because of various practical issues, e.g. the lack of a standardized matrix preparation. The aim of this study was to develop and validate a convenient DBPCFC matrix, that can easily be implemented i...
متن کاملبررسی شیوه کورسازی، نوع مداخله و حوزههای موضوعی در کارآزماییهای بالینی تصادفی کنترل شده
Background and Aim: Randomized controlled clinical trial is the most valid type of epidemiological studies for the treatment of diseases. The aim of the present article is to determine the subject area, type of intervention, and blinding methods used in this type of study design. Materials and Methods: This is a cross-sectional descriptive study in which all the articles based on randomized c...
متن کاملDouble-blind food challenges in children in general paediatric practice: useful and safe, but not without pitfalls.
OBJECTIVE To describe results of double-blind placebo-controlled food challenges (DBPCFC) with cow's milk, hen's egg, soy, peanut and hazelnut in general paediatric practice. METHODS Food challenges were performed between January 2006 and June 2011, in children 0-18 years of age, on two half-day hospital admissions with a one-week interval. Tests were performed in a double-blind fashion follo...
متن کامل